Duke vs. Arizona Prediction: Expert Picks, Odds, Stats and Best Bets – NCAA Tournament Sweet 16 - Bleacher Nation (2025)

The No. 1 seed Duke Blue Devils (33-3) and the No. 4 seed Arizona Wildcats (24-12) meet in the NCAA Tournament Sweet 16 with a place in the Elite Eight on the line on Thursday at Prudential Center, tipping off at 9:39 p.m. ET. Duke is a 9.5-point favorite in the matchup, which airs on CBS. The matchup has a point total of 153.5.

Duke vs. Arizona Odds

  • Duke odds to win: -549
  • Arizona odds to win: +410
  • Spread: Duke (-9.5)
  • Total: 153.5
  • Duke vs. Arizona Promo Codes

    Game Time and Information

  • Date: Thursday, March 27, 2025
  • Time: 9:39 p.m. ET
  • TV: CBS
  • Where: Newark, New Jersey
  • Venue: Prudential Center
  • Who Will Win Duke vs. Arizona?

    Duke and Arizona Betting Trends, Records Against the Spread

    Duke has an 18-8 record against the spread this season when favored by 9.5 points or more.

    The two teams average a combined 11.9 more points per game (165.4) than this game’s over/under of 153.5 points.

    Duke and Arizona have seen their opponents average a combined 19.3 fewer points per game than the over/under of 153.5 set in this outing.

    Duke’s average point total in outings this year is 144.8, 8.7 points less than the total in this game.

    The average point total for the Wildcats this year is 1.2 points higher than this game’s over/under.

    The Blue Devils are 24-12-0 ATS this season.

    The Wildcats are 19-17-0 against the spread this year.

    Duke Stats & Insights

    Duke’s +774 scoring differential (outscoring opponents by 21.5 points per game) is a result of scoring 83.2 points per game (12th in college basketball) while allowing 61.7 per outing (sixth in college basketball).

    Duke wins the rebound battle by an average of 8.7 boards. It is pulling down 35.9 rebounds per game (19th in college basketball) compared to its opponents’ 27.2 per contest.

    The Blue Devils knock down 3.5 more threes per contest than the opposition, 10.3 (18th in college basketball) compared to their opponents’ 6.8.

    Duke ranks first in college basketball by averaging 110.9 points per 100 possessions on offense, and defensively is fourth in college basketball, allowing 82.2 points per 100 possessions.

    The Blue Devils are scoring 85.5 points per game this year when playing at home, which is 5.5 more points than they’re averaging away from home (80.0).

    Arizona Stats & Insights

    Arizona puts up 82.2 points per game (17th in college basketball) while allowing 72.5 per outing (197th in college basketball). It has a +348 scoring differential and outscores opponents by 9.7 points per game.

    Arizona ranks 11th in college basketball at 36.8 rebounds per game. That’s 8.2 more than the 28.6 its opponents average.

    Arizona connects on 1.5 fewer threes per game than the opposition, 7.1 (246th in college basketball) compared to its opponents’ 8.6.

    Arizona averages 102.1 points per 100 possessions on offense (42nd in college basketball), and concedes 90.1 points per 100 possessions (86th in college basketball).

    In 2024-25 the Wildcats are averaging 11.5 more points per game at home (87.3) than on the road (75.8).

    Duke Key Players to Watch

    The Blue Devils leader in points, rebounds and assists is Cooper Flagg, who puts up 18.7 points, 7.5 boards and 4.1 assists per game.

    The Blue Devils get the most three-point shooting production out of Tyrese Proctor, who knocks down 2.5 threes per game.

    The Duke leader in both steals and blocks is Flagg, who averages 1.4 takeaways and 1.2 rejections per game.

    Arizona Key Players to Watch

    Caleb Love puts up 16.8 points per game and is the top scorer for the Wildcats.

    Arizona’s leader in rebounds is Tobe Awaka with 8.0 per game, and its leader in assists is Jaden Bradley with 3.6 per game.

    Love is consistent from deep and leads the Wildcats with 2.6 made threes per game.

    Bradley (1.8 steals per game) is the steal leader for Arizona while Henri Veesaar (1.1 blocks per game) is the block leader.

    Duke vs. Arizona Prediction

  • Pick ATS: Arizona (+9.5)
  • Pick OU: Under (153.5)
  • Prediction:
    Duke 79, Arizona 70
  • How to Bet on Duke vs. Arizona

    And for more CBB game previews, NCAA basketball picks or even how to bet on college basketball check out the latest NCAAB lines on Betsperts.

    Duke vs. Arizona Prediction: Expert Picks, Odds, Stats and Best Bets – NCAA Tournament Sweet 16 - Bleacher Nation (2025)
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